Phenoxy compounds

Organic compounds that have one or more phenyl groups that are bonded to an oxygen with a radical electron; includes compounds with additional substitutions.

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421 – 435 of 2,528 results

421

eMolecules Medchem Express / Firsocostat / 5mg / 446267909 / HY-16901 / / 1434635-54-7 / MFCD28963986 / 569.630 / C28H31N3O8S

Medchem Express / Firsocostat / 5mg / 446267909 / HY-16901 / / 1434635-54-7 / MFCD28963986 / 569.630 / C28H31N3O8S

Pricing & Availability

422

eMolecules Trimetazidine dihydrochloride | 13171-25-0 | MFCD00243086 | 25g

Matrix Scientific | Trimetazidine dihydrochloride | 25g | 389717704 | 12231 | 95.000 | 13171-25-0 | MFCD00243086 | 339.260 | C14H24Cl2N2O3

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423

eMolecules Medchem Express / RN-1747 / 5mg / 552386777 / HY-19976 / / 1024448-59-6 / MFCD04154169 / 395.860 / C17H18ClN3O4S

Medchem Express / RN-1747 / 5mg / 552386777 / HY-19976 / / 1024448-59-6 / MFCD04154169 / 395.860 / C17H18ClN3O4S

Pricing & Availability

424

Medchemexpress LLC Tucatinib hemiethanolate | 1429755-56-5 | 98.8% | 503.57 | 5 MG

Tucatinib hemiethanolate is a potent, orally active, and selective HER2 inhibitor (IC50: 8 nM) with ~500-fold selectivity over EGFR in cell-based assays. It selectively blocks proliferation and phosphorylation of HER2 and its downstream effector, Akt, in HER2 overexpressing cell lines, offering potential to block HER2 signaling without the toxicities associated with EGFR inhibition.

Potent, orally active, selective HER2 inhibitor.
Exhibits ~500-fold selectivity for HER2 over EGFR.
Blocks HER2 proliferation and Akt phosphorylation.
May avoid EGFR inhibition toxicities.
Shows survival benefit and reduces brain pErbB2 in animal models.
Demonstrates significant dose-related tumor growth inhibition.
Combined with trastuzumab, shows 98% tumor growth inhibition.

Pricing & Availability

425

Medchemexpress LLC Mardepodect hydrochloride | 2070014-78-5 | 99.9% | C25H21ClN4O | 100 MG

Mardepodect hydrochloride is a potent, orally active, and selective PDE10A inhibitor with an IC50 of 0.37 nM. It demonstrates over 1000-fold selectivity compared to other PDEs and is capable of crossing the blood-brain barrier.

Potent and orally active
Selective PDE10A inhibitor
IC50 of 0.37 nM
Over 1000-fold selectivity over other PDEs
Crosses the blood-brain barrier
Active in conditioned avoidance response assay (CAR) with an ED50 of 1 mg/kg
Increases striatal cGMP dose-dependently in mice

Pricing & Availability

426

Medchemexpress LLC 2-(Hydroxy(4-phenoxyphenyl)methylene)malononitrile | 330792-68-2 | C16H10N2O2 | 100 MG

This product is a laboratory chemical intended for research use only, suitable for the manufacture of substances. It should be handled by experienced personnel in appropriately equipped facilities and has not been fully validated for medical applications.

Identified uses: laboratory chemicals, manufacture of substances.
Appearance: solid.
Melting/freezing point: 160-161.2°C.
Recommended storage for powder: -20°C for 3 years, 4°C for 2 years.
Recommended storage in solvent: -80°C for 6 months, -20°C for 1 month.
Shipping at room temperature if less than 2 weeks.

Pricing & Availability

427

Medchemexpress LLC D-64131 | 74588-78-6 | C16H13NO2 | 100 MG

D-64131 is an orally active tubulin inhibitor with an IC50 of 0.53 μM for tubulin polymerization. It exhibits antimitotic activity and can be utilized for cancer research. It is antimitotic by binding to β-tubulin, destabilizing microtubules, and arresting mitotic cells in the M-phase. This compound inhibits the proliferation of tumor cells from various organs and tissues, including cytotoxicity against MDR/MRP tumor cell lines.

Exhibits antimitotic activity
Useful in cancer research
Inhibits tumor cell proliferation
Cytotoxic against MDR/MRP tumor cell lines
Suppresses U373 proliferation and cell cycle
Significantly inhibits tumor growth in human amelanoic melanoma xenograft models
Possesses oral bioavailability
Well tolerated at efficacious doses

Pricing & Availability

428

Medchemexpress LLC Prexasertib dimesylate (LY2606368 dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 100 MG

Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound causes double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.

Selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor.
Inhibits CHK2 and RSK1.
Causes double-stranded DNA breakage and replication catastrophe.
Induces apoptosis.
Shows potent anti-tumor activity.

Pricing & Availability

429

Medchemexpress LLC Bambuterol-d9 hydrochloride | 1794810-59-5 | 99.88% | 412.96 | 1 MG

Bambuterol-d9 (hydrochloride) is the deuterium labeled Bambuterol. Bambuterol ((±)-Bambuterol) hydrochloride is a long-acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma, and it is also a prodrug of terbutaline.

This compound can be used as a tracer.
This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

Pricing & Availability

430

Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 5 MG

Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.

Selective, ATP-competitive CHK1 inhibitor
Inhibits CHK1 (Ki 0.9 nM, IC50 <1 nM), CHK2, and RSK1
Induces double-stranded DNA breakage and replication catastrophe
Leads to apoptosis and potent anti-tumor activity
Inhibits MELK, SIK, BRSK2, and ARK5
Requires CDC25A and CDK2 for DNA damage
Causes DNA damage during S-phase
Inhibits CHK1 and CHK2 autophosphorylation
Induces cell-cycle shift with H2AX phosphorylation
Triggers chromosomal fragmentation and replication stress

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431

Medchemexpress LLC 4-Phenoxybenzylamine | 107622-80-0 | 98.45% | 199.25 | 50 MG

4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation. This action targets a highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein, representing a new class of direct acting antiviral agents.

Inhibits NS3 protein function
Stabilizes inactive conformation of NS3 protein
Targets highly conserved novel binding site
Acts as a direct acting antiviral agent

Pricing & Availability

432

Medchemexpress LLC Eltoprazine hydrochloride | 98206-09-8 | 99.3% | 256.73 | 100 MG

Eltoprazine hydrochloride is an agonist for 5-HT1A/5-HT1B receptors and an antagonist for 5-HT2C receptors, demonstrating antiaggressive and anxiogenic effects.

Agonist for 5-HT1A/5-HT1B receptors
Antagonist for 5-HT2C receptors
Shows antiaggressive effects
Shows anxiogenic effects
Target: 5-HT Receptor
Pathway: GPCR/G Protein, Neuronal Signaling

Pricing & Availability

433

Medchemexpress LLC Quercetin-7-O-β-D-glucopyranoside | 491-50-9 | 464.38 | 5 MG

Quercimeritrin is an orally active α-glucosidase inhibitor and a P-gp substrate, demonstrating anti-angiogenic and antioxidant activities. It effectively regulates postprandial blood glucose and exhibits significant anti-angiogenic activity, inhibiting endothelial cell proliferation and microvascular growth, suggesting its potential in diabetes and breast cancer research.

Orally active α-glucosidase inhibitor
P-gp substrate with anti-angiogenic and antioxidant activities
Regulates postprandial blood glucose
Inhibits endothelial cell proliferation and microvascular growth
Potential utility in diabetes and breast cancer research

Pricing & Availability

434

Medchemexpress LLC Beta-asarone (standard) | 5273-86-9 | 208.25 | 5 MG

Beta-asarone is an orally active and BBB-penetrable anti-inflammatory and neuroprotective agent, which is the major ingredient of Acorus tatarinowii Schott. It can protect nerve cells from apoptosis and autophagy, inhibit expression of α-synuclein, and provides myocardial protection. Beta-asarone can be used in the study of neurological and cardiovascular diseases.

Orally active
BBB-penetrable anti-inflammatory and neuroprotective agent
Protects nerve cells from apoptosis and autophagy
Inhibits α-synuclein expression
Offers myocardial protection
Useful for studying neurological and cardiovascular diseases

Pricing & Availability

435

Medchemexpress LLC Neuromedin N (swine spinal cord), 2-L-lysine-, triacetate (salt) | 141863-45-8 | 99.69% | 807.03 | 5 MG

JMV 449 acetate is a potent neurotensin receptor agonist. It has an IC50 of 0.15 nM for inhibiting 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. This compound also exhibits highly potent and long-lasting hypothermic and analgesic effects in mice.

Potent neurotensin receptor agonist
IC50 of 0.15 nM for inhibiting 125I-neurotensin binding to neonatal mouse brain
EC50 of 1.9 nM in contracting the guinea-pig ileum
Highly potent and long-lasting hypothermic effects
Highly potent and long-lasting analgesic effects
Shows analgesic effect in male Swiss albino mice

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Phenoxy compounds

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Medchemexpress LLC Tucatinib hemiethanolate | 1429755-56-5 | 98.8% | 503.57 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mardepodect hydrochloride | 2070014-78-5 | 99.9% | C25H21ClN4O | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-(Hydroxy(4-phenoxyphenyl)methylene)malononitrile | 330792-68-2 | C16H10N2O2 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC D-64131 | 74588-78-6 | C16H13NO2 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Prexasertib dimesylate (LY2606368 dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bambuterol-d9 hydrochloride | 1794810-59-5 | 99.88% | 412.96 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 4-Phenoxybenzylamine | 107622-80-0 | 98.45% | 199.25 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Eltoprazine hydrochloride | 98206-09-8 | 99.3% | 256.73 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Quercetin-7-O-β-D-glucopyranoside | 491-50-9 | 464.38 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Beta-asarone (standard) | 5273-86-9 | 208.25 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Neuromedin N (swine spinal cord), 2-L-lysine-, triacetate (salt) | 141863-45-8 | 99.69% | 807.03 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More